F7DIMH - Hyperthermia

Randomized clinical trials (RCT’s) have been shown significant improvement in clinical outcome when hyperthermia was added to radiotherapy and/or chemotherapy. According to the standards set by the Society of Thermal Medicine (STM); European Society for Hyperthermic Oncology (ESHO) and the Asian Society of Hyperthermic Oncology (ASHO); the benefits of hyperthermia are fully realized when the tumor temperature reaches 39-43 degrees Celsius. The course aims to introduce the benefits of Hyperthermia in Cancer Treatment as well as to introduce the hardware and software equipment.

In the case of foreign lecturers, there will be a weeklong block of intensive contact education for the number of students at least five. If the number of students is less than five, the course will be self-study with consultations using VoIP (e.g. Skype) and a contact 1-or 2-day seminar. The contact seminar will take place at the FBMI or at the home institution of a foreign lecturer. The subjects are concluded by an oral examination. The student must elaborate a paper on a given topic together with the exam in case of the controlled self-study.

Two laboratory exercises are required for admission to the exam (attested by a protocol signed by the student, the tutor and the supervisor of the course).

The protocols will be archived in the Department for Doctoral Studies.

Lectures:

1. Thermal biology - hyperthermia and ablation

2. Tumour biology and Physiology

3. Biological basis of thermal dose

4. Bio-heat equation

5. Thermal properties of tissues, Vascular cooling

6. Temperature measurement

7. RF & Microwaves

8. High Intensity Focused ultrasound

9. Heat + radiotherapy, Heat + drugs Novel treatment approaches

10. Clinical Cases: Deep hyperthermia, Superficial hyperthermia, Ultrasound in the brain.

Laboratory:

1. Creating 3D models by segmenting CT images

2. Treatment Planning for Microwave Hyperthermia

Randomized clinical trials (RCT’s) have been shown significant improvement in clinical outcome when hyperthermia was added to radiotherapy and/or chemotherapy. According to the standards set by the Society of Thermal Medicine (STM); European Society for Hyperthermic Oncology (ESHO) and the Asian Society of Hyperthermic Oncology (ASHO); the benefits of hyperthermia are fully realized when the tumor temperature reaches 39-43 degrees Celsius. The course aims to introduce the benefits of Hyperthermia in Cancer Treatment as well as to introduce the hardware and software equipment.

Required:

[1] Wust P."THERMOTHERAPY IN ONCOLOGY UNI-MED, Science, 1st edition 2016,

Recommended:

[1] N. Cihoric, A. Tsikkinis, G. van Rhoon, H. Crezee, D. M. Aebersold, S. Bodis, M. Beck, J. Nadobny, V. Budach, P. Wust, and P. Ghadjar, "Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry,” Int J Hyperthermia, vol. 31, no. 6, pp. 609-14, Sep, 2015.

[2] M. M. Paulides, P. R. Stauffer, E. Neufeld, P. F. Maccarini, A. Kyriakou, R. A. Canters, C. J. Diederich, J. F. Bakker, and G. C. Van Rhoon, "Simulation techniques in hyperthermia treatment planning,” Int J Hyperthermia, vol. 29, no. 4, pp. 346-57, Jun, 2013.

[3] J. E. Johnson, D. G. Neuman, P. F. Maccarini, T. Juang, P. R. Stauffer, and P. Turner, "Evaluation of a dual-arm Archimedean spiral array for microwave hyperthermia,” International Journal of Hyperthermia, vol. 22, no. 6, pp. 475-490, Sep. 2006.

Modul D