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F7AMBSF - Systemic Physiology

Code Completion Credits Range Language
F7AMBSF Z,ZK 5 2P+2L English
Lecturer:
Ksenia Sedova
Tutor:
Ksenia Sedova
Supervisor:
Department of Biomedical Technology
Synopsis:

The course deals with the following themes: functional organisation of living systems, basic concepts of system approach to integrated functions of the human organism, importance of systems offering the use for biomedical technicians and engineers, examples of some experimental and investigative methods and modern technologies used in physiology and medicine. Lectures contain also problem solving.

Requirements:

Prerequisites

Laboratory sessions have to be documented within 14 days by reports submitted in electronic or printed forms. Reportss are evaluated and the obtained score accounts for 35% in the final evaluation. Students who did participate in a laboratory session but did not submit the corresponding report may access to final examinations but with 0 credit for the non documented session.

Examination:

Written test: multiple choice questions combined with problem solvings that takes 3 hours and consists of 12-15 questions. Only students with 100% presence (all absences compensated) in the laboratory sessions are accepted for the examination. Assessment according to the ECTS criteria.

Syllabus of lectures:

1.Introduction. System biology, system physiology in medicine. Thermodynamics of living systems. Principles and classification of biological transports. Structure and basic functions of a cell.

2.From cell to tissues and organs. Energetic: genesis and use of chemical, mechanical, electrical and thermal energy. Functional hierarchy and cooperativeness in living organisms, principles of homeostasis and adaptation. Experimental approach and modelling.

3.Circulatory and respiratory systems. Principles of exchanges and transports of fluids and gases. Cardiac automatism, mechanics (functional imaging) and energetic. Microcirculation and capillary exchanges. Cardio-respiratory regulatory mechanisms and relationships with acid-base balance. Investigation of respiratory and cardiovascular functions. Principles of cardio-respiratory assistance, angioplasty, and pacemaker and valve implantation.

4.Excretion system. Physical principles of the urine formation. Functional polarity of epithelial cells. Homeostasis of capitals, volumes and compositions of human electrolytic compartments. Interrelationships among renal, respiratory and circulatory systems. Investigation of renal functions. Haemodialysis.

5Digestive system. Physical and chemical principles of digestive functions. Motility of the digestive tube (animated models) and its control (enteric nervous system and microbiom). Telemetric investigations of digestive functions (smart pills, magnet tracking system).

6Neuro-muscular system. Principles of neural A/D a D/A conversion. Binary nature of action potential, its propagation and analogical, mathematical and molecular representation. Principles and investigation of postural and movement functions. Organisation of motor programs. Brain functional mapping. Introduction into cognitive functions.

Syllabus of tutorials:

1.Haemolysis - spectrophotometry

2.Voltage-clamp – active and passive epithelial transports

3.Ergospirometry – indirect calorimetry

4.Elektromyography – excitability, signal propagation, reflex

5.ECG – investigation of cardiac electrical signals

6.Urine: creatinin, clearance, glomerular filtration

7.Cellular experiments (AV ČR Praha).

Study Objective:
Study materials:

Mandatory:

1.HALL, John E. a Arthur C. GUYTON. Guyton and Hall textbook of medical physiology. 12th ed. Philadelphia: Saunders/Elsevier, c2011. ISBN 978-1-4160-4574-8.

2.SILVERTHORN, Dee Unglaub. Human physiology: an integrated approach. Eight edition. Ilustroval William C. OBER, ilustroval Claire E. OBER, ilustroval Anita IMPAGLIZZO. San Francisco: Pearson, 2019. ISBN 978-0-13-460519-7.

3.SILBERNAGL, Stefan a Agamemnon DESPOPOULOS. Color atlas of physiology. 7th edition. Stuttgart: Thieme, 2015. Thieme Flexibook. ISBN 978-3-13-545007-0.

Recommended::

1.CHAPPELL, Michael a Stephen PAYNE. Physiology for engineers: applying engineering methods to physiological systems. Cham: Springer, 2016. Biosystems & biorobotics. ISBN978-3-319-26195-9.

2.Medical physiology: a cellular and molecular approach. 2nd ed. Editor Walter F. BORON, editor Emile L. BOULPAEP. Philadelphia: Saunders/Elsevier, c2009. ISBN 978-1-4160-3115-4.

3.SHIER, David, Jackie BUTLER a Ricki LEWIS. Hole's human anatomy & physiology. 13th ed. New York: McGraw - Hill, c2013. ISBN 978-0-07-131796-2.

Note:
The course is a part of the following study plans:
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