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F7ADIPPCS - Physiology and Pathophysiology of Cardiovascular System

Code Completion Credits Range Language
F7ADIPPCS ZK 20P+8C English
Lecturer:
Ian Azarov (guarantor)
Tutor:
Ian Azarov (guarantor)
Supervisor:
Department of Biomedical Technology
Synopsis:

The course provides with basic and applied information on the physiological processes in the cardiovascular system. It mostly concerns the questions how to assess different conditions of heart and circulation on the basis of instrumentally measured physiological variables (a diagnostic perspective). After completion, students will be able to analyze physiological parameters, such as ECG, arterial blood pressure, heart rate, etc; solve typical problems in the cardiovascular “domain”; and will learn conceptual approaches for the application of physiological knowledge in cardiology.

Requirements:

The subjects are concluded by an oral examination preceded by a written test. The student must elaborate a paper on a given topic together with the exam in case of the controlled self-study.

Syllabus of lectures:

Lectures

1. Physiology of cardiac myocytes – ion channels and ionic currents, membrane potentials, contractile properties, cellular targets for heart diseases.

2. Generation of heart rhythm and activation spread – pacemakers, atrioventricular conduction, myocardial depolarization and repolarization, ECG.

3. Arrhythmogenesis – impulse generation abnormalities, conduction abnormalities, reentry.

4. The heart as a pump – cardiac cycle, cardiac output, arterial blood pressure, targets for autonomic regulation.

5. Circulation – systemic hemodynamics, control of local bloodflows and arterial blood pressure, hierarchy of circulation regulation.

6. Abnormal circulation, part 1 – hypotension and syncope, ischemia, circulatory shock.

7. Abnormal circulation, part 2 – essential arterial hypertension, pulmonary arterial hypertension.

8. Myocardial ischemia, part 1 – coronary circulation, oxygen demand and supply.

9. Myocardial ischemia, part 2 – atherosclerosis, stenosis, thrombosis, myocardial infarction.

10. Heart failure – cellular, organ and systemic mechanisms.

Syllabus of tutorials:

Exercises

1. Short- and long-term control of hemodynamics – cardiovascular parameters for evaluation of circulation.

2. Heart failure – cardiovascular parameters for evaluation of circulation.

Study Objective:

The course provides with basic and applied information on the physiological processes in the cardiovascular system. It mostly concerns the questions how to assess different conditions of heart and circulation on the basis of instrumentally measured physiological variables (a diagnostic perspective). After completion, students will be able to analyze physiological parameters, such as ECG, arterial blood pressure, heart rate, etc; solve typical problems in the cardiovascular “domain”; and will learn conceptual approaches for the application of physiological knowledge in cardiology.

Study materials:

Required:

[1] J.Hall. Guyton and Hall Textbook of Medical Physiology. 13th ed. Elsevier (2016);

[2] L.Lilly. Pathophysiology of Heart Disease. 6th ed. Wolters Kluwer (2016);

Recommended:

[1] J.Hall. Guyton and Hall Physiology Review. 3rd ed. Elsevier (2016);

[2] D.Zipes, P.Libby. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 11th ed. Elsevier (2019).

Note:
The course is a part of the following study plans:
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