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F7ADIMH - Microwave Hyperthermia

Code Completion Credits Range Language
F7ADIMH ZK 20P+8C English
Lecturer:
Gerard Van Rhoon (guarantor)
Tutor:
Gerard Van Rhoon (guarantor)
Supervisor:
Department of Biomedical Technology
Synopsis:

Randomized clinical trials (RCT’s) have been shown significant improvement in clinical outcome when hyperthermia was added to radiotherapy and/or chemotherapy. According to the standards set by the Society of Thermal Medicine (STM); European Society for Hyperthermic Oncology (ESHO) and the Asian Society of Hyperthermic Oncology (ASHO); the benefits of hyperthermia are fully realized when the tumor temperature reaches 39-43 degrees Celsius. The course aims to introduce the benefits of Hyperthermia in Cancer Treatment as well as to introduce the hardware and software equipment.

Requirements:

The subjects are concluded by an oral examination. The student must elaborate a paper on a given topic together with the exam in case of the controlled self-study. Assessment will be based on active participation in the discussion exercises, reports of group work and presentation of the research protocol conducted during the workshop.

Syllabus of lectures:

Lectures:

1. Thermal biology – hyperthermia & ablation

2. Tumour biology & Physiology

3. Biological basis of thermal dose

4. Bio-heat equation

5. Thermal properties of tissues, Vascular cooling

6. Temperature measurement

7. RF & Microwaves

8. High Intensity Focused ultrasound

9. Heat + radiotherapy, Heat + drugs Novel treatment approaches

10. Clinical Cases: Deep hyperthermia, Superficial hyperthermia, Ultrasound in the brain.

Syllabus of tutorials:

Laboratory:

1. Creating 3D models by segmenting CT images

2. Treatment Planning for Microwave Hyperthermia

Study Objective:

Randomized clinical trials (RCT’s) have been shown significant improvement in clinical outcome when hyperthermia was added to radiotherapy and/or chemotherapy. According to the standards set by the Society of Thermal Medicine (STM); European Society for Hyperthermic Oncology (ESHO) and the Asian Society of Hyperthermic Oncology (ASHO); the benefits of hyperthermia are fully realized when the tumor temperature reaches 39-43 degrees Celsius. The course aims to introduce the benefits of Hyperthermia in Cancer Treatment as well as to introduce the hardware and software equipment.

Study materials:

Required:

[1] Wust P.“THERMOTHERAPY IN ONCOLOGY UNI-MED, Science, 1st edition 2016,

Recommended:

[1] N. Cihoric, A. Tsikkinis, G. van Rhoon, H. Crezee, D. M. Aebersold, S. Bodis, M. Beck, J. Nadobny, V. Budach, P. Wust, and P. Ghadjar, “Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry,” Int J Hyperthermia, vol. 31, no. 6, pp. 609-14, Sep, 2015.

[2] M. M. Paulides, P. R. Stauffer, E. Neufeld, P. F. Maccarini, A. Kyriakou, R. A. Canters, C. J. Diederich, J. F. Bakker, and G. C. Van Rhoon, “Simulation techniques in hyperthermia treatment planning,” Int J Hyperthermia, vol. 29, no. 4, pp. 346-57, Jun, 2013.

[3] J. E. Johnson, D. G. Neuman, P. F. Maccarini, T. Juang, P. R. Stauffer, and P. Turner, “Evaluation of a dual-arm Archimedean spiral array for microwave hyperthermia,” International Journal of Hyperthermia, vol. 22, no. 6, pp. 475-490, Sep. 2006.

Note:
The course is a part of the following study plans:
Downloads: