F7ADIMH - Microwave Hyperthermia

Randomized clinical trials (RCTs) have been shown significant improvement in clinical outcome when hyperthermia was added to radiotherapy and/or chemotherapy. According to the standards set by the Society of Thermal Medicine (STM); European Society for Hyperthermic Oncology (ESHO) and the Asian Society of Hyperthermic Oncology (ASHO); the benefits of hyperthermia are fully realized when the tumor temperature reaches 39-43 degrees Celsius. The course aims to introduce the benefits of Hyperthermia in Cancer Treatment as well as to introduce the hardware and software equipment.

The subjects are concluded by an oral examination. The student must elaborate a paper on a given topic together with the exam in case of the controlled self-study. Assessment will be based on active participation in the discussion exercises, reports of group work and presentation of the research protocol conducted during the workshop.

Lectures:

1. Thermal biology hyperthermia & ablation

2. Tumour biology & Physiology

3. Biological basis of thermal dose

4. Bio-heat equation

5. Thermal properties of tissues, Vascular cooling

6. Temperature measurement

7. RF & Microwaves

8. High Intensity Focused ultrasound

9. Heat + radiotherapy, Heat + drugs Novel treatment approaches

10. Clinical Cases: Deep hyperthermia, Superficial hyperthermia, Ultrasound in the brain.

Laboratory:

1. Creating 3D models by segmenting CT images

2. Treatment Planning for Microwave Hyperthermia

Randomized clinical trials (RCTs) have been shown significant improvement in clinical outcome when hyperthermia was added to radiotherapy and/or chemotherapy. According to the standards set by the Society of Thermal Medicine (STM); European Society for Hyperthermic Oncology (ESHO) and the Asian Society of Hyperthermic Oncology (ASHO); the benefits of hyperthermia are fully realized when the tumor temperature reaches 39-43 degrees Celsius. The course aims to introduce the benefits of Hyperthermia in Cancer Treatment as well as to introduce the hardware and software equipment.

Required:

[1] Wust P.THERMOTHERAPY IN ONCOLOGY UNI-MED, Science, 1st edition 2016,

Recommended:

[1] N. Cihoric, A. Tsikkinis, G. van Rhoon, H. Crezee, D. M. Aebersold, S. Bodis, M. Beck, J. Nadobny, V. Budach, P. Wust, and P. Ghadjar, Hyperthermia-related clinical trials on cancer treatment within the ClinicalTrials.gov registry, Int J Hyperthermia, vol. 31, no. 6, pp. 609-14, Sep, 2015.

[2] M. M. Paulides, P. R. Stauffer, E. Neufeld, P. F. Maccarini, A. Kyriakou, R. A. Canters, C. J. Diederich, J. F. Bakker, and G. C. Van Rhoon, Simulation techniques in hyperthermia treatment planning, Int J Hyperthermia, vol. 29, no. 4, pp. 346-57, Jun, 2013.

[3] J. E. Johnson, D. G. Neuman, P. F. Maccarini, T. Juang, P. R. Stauffer, and P. Turner, Evaluation of a dual-arm Archimedean spiral array for microwave hyperthermia, International Journal of Hyperthermia, vol. 22, no. 6, pp. 475-490, Sep. 2006.