F7ADIBMC - Biophysical Modeling in Cardiology

The course provides with basic and applied information on the genesis of the ECG, VCG, electric volume conduction, forward and inverse problem in electrocardiology eventually also on mechanical heart modeling (CircAdapt).

The subjects are concluded by an oral examination preceded by a written preparation (written test using available simulation tools). The student must elaborate a paper on a given topic together with the exam in case of the controlled self-study.

The study is performed in the form of controlled self-study with regular consultations and obligatory participation in laboratory exercises.

1. Electrical functioning of the heart: Clinical Aspects

2. Electrical functioning of the heart: electro-physiology

3. The ECG: signal analysis

4. Electrical functioning of the heart: Modeling I (source models)

5. Electrical functioning of the heart: Modeling II (volume conduction)

6. Electrical functioning of the heart: Modeling III (specific disease modeling, ACM)

7. ECGsim

8. The inverse problem in electrocardiography I

9. The inverse problem in electrocardiography II

10. SciRun, solving an inverse problem.

1. Simulation of the ECG.

2. Inverse problem solving. Datasets will be available to solve the inverse problem suing SCirun. Base on these work an end report needs to be created.

The course provides with basic and applied information on the genesis of the ECG, VCG, electric volume conduction, forward and inverse problem in electrocardiology eventually also on mechanical heart modeling (CircAdapt).

Required:

[1] Barr R.C., van Oosterom A. (2010) Genesis of the Electrocardiogram. In: Macfarlane P.W., van Oosterom A., Pahlm O., Kligfield P., Janse M., Camm J. (eds) Comprehensive Electrocardiology. Springer, London

[2] T. F. Oostendorp and A. van Oosterom, „Source parameter estimation in inhomogeneous volume conductors of arbitrary shape,“ in IEEE Transactions on Biomedical Engineering, vol. 36, no. 3, pp. 382-391, March 1989.

Recommended:

[1] A. van Oosterom. T.F. Oostendorp. Electric Volume Conduction in Bio-medicine. Laboratory of Medical Physics and Biophysics Catholic University Nijmegen, Nijmegen. The Netherlands. April 2015.