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17AMBBTR - Biotransport

Dear students, lectures will be realized in blocks in weeks from 27. 4. to 25. 5. Practical lessons will be also realized in blocks during the semester.

Code Completion Credits Range Language
17AMBBTR Z,ZK 4 2P+2C English
Lecturer:
Tutor:
Supervisor:
Department of Biomedical Technology
Synopsis:

Transport processes are underlying all functions of living organisms. Mechanisms by which these processes take place, and models that describe them, are the subjects of this course. From the principles of thermo-dynamics and the organization of the cell, the transports will be described in terms of their molecular structure, their function and features, and their integration into tissues and organs. The courses will be of interest to Student who wish to understand and interpret transport experiments in biological systems and to predict performance or behavior from transport data.

Requirements:

Requirements for assessment:

- written answers to all given problems and tasks,

- submitted all protocols from all practical lessons.

Exam requirements:

- obtained assessment,

- written exam contains some questions QCM, interpretation of the graph, the solution (calculation) of the practical problem.

Evaluation (grading) of the written exam according to the ECTS grading scale at CTU.

Syllabus of lectures:

1 General aspects

Equations describing transports; coupled transports, consequences of transports in human body, thermodynamic approach and modeling, homeostasis of living systems, from single cell to cell community.

2 Transmembrane and transcellular transports

Classification, barriers, kinetics, energetics, transport of proton and electron. Synthesis of ATP. Ultrafiltration, secretion-absorption, transcytosis. Methods to study transports.

3 Major convective transports:

Blood circulation and gas exchanges. Importance and functional links of cardiovascular and respiratory systems. Microcirculation and capillary exchanges. Alveolo-capillary exchanges and blood transport of gases, biological roles of oxygen and carbon dioxide. Distribution and regulations of cardiac output and of oxygen uptake. Technological approach to hypoxia and ischemia.

Transports of nutrients and wastes.

Special lecture „Investigation of digestive motility: from idea to clinical use“.

Overview of renal functions (intra- et extracellular fluids, urine). Investigation (balances among glomerular and tubular functions). Transport of NaCl and water (osmoregulation). Acid-base regulation. Hemodialysis.

4 Transport of information

Basis of excitability and signal propagation. Neuron as functional unit. Principles of synaptic transmission and organization. Principles of memory formation. Neuromuscular system: from motor unit to voluntary act. Introduction into cognitive functions. Integration: back to homeostasis (health and disease from point of view of transports).

Syllabus of tutorials:

1.Membrane thermodynamics

2.The Cell

3.Membrane proteins

4.Neural signaling

5.Genesis and use of mechanical force

6.Transcellular transports

7.Gas transports

8.Transports in artificial organs

Study Objective:

- To get a solid view on transfer of mater, energy and information in living

systems.

- To realize that transport processes are basis of life.

- To review principles of investigative methodes used in physiology and

medicine.

- To stimulate the use of knowledge in solving practical problems.

Study materials:

1.Kucera P.: documents and outlines of lectures given in advance.

2.Fournier, Ronald L.: Basic transport phenomena in biomedical engineering. 2nd ed. New York: Taylor & Francis, 2007. 450 p. ISBN-13: 9781591690269, ISBN-10: 1591690269 (recommended)

3.Truskey, G.A. Yuan, F., and Katz, D.: Transport Phenomena in Biological

Systems. 1st ed. Prentice Hall, New Jersey, USA, 2004. 811 pp. (2nd ed. 2009)

4.Morton H. Friedman: Principles and Models of Biological Transport, 2nd ed. Springer, 2008, 510 p. 150 illus., ISBN: 978-0-387-79239-2 (for deeper understanding and mathematical formulations

Note:
The course is a part of the following study plans:
Downloads:

Lectures - link: 

Exercises: 
AttachmentSize
PDF icon Ergometry397.97 KB
PDF icon Voltage clamp692.9 KB
PDF icon Hemolysis225.86 KB
PDF icon Electromyography670.98 KB
PDF icon Creatinine and urine examination490.42 KB

Exercises - link: