You are here

17ABBFCH - Physical Chemistry

Code Completion Credits Range Language
17ABBFCH Z,ZK 4 2P+1S+1L English
Enrollement in the course requires an successful completion of the following courses:
Chemistry (17ABBCHM)
Karel Roubík (guarantor)
Karel Roubík (guarantor), Kristýna Poncová
Department of Biomedical Technology

Mixtures of compounds. Vapour and vaporisation. Electrodes. Electrochemical potential, electrodes. Referent and measuring electrodes, ECG, EEG and EMG electrodes. Redox potential. Inert electrodes. Membranes. Osmotic pressure. Ion-sensitive electrodes. Acidity. Measurement of pH, pO2, pCO2. Electrolysis and its application. Corrosion and protection of implants. Other amalytical methods based on principles of physical chemistry.


Conditions of credit:

Obligatory and active attendance at all tutorials. Absences are acceptable for serious reasons only and must be apologized and recompensed. Student has to come in time. For each lab session working out a report in corresponding quality. For the attendance at each lab session student has to pass an entrance test at least for 60 %. In the other way, he has to recompense the session with the test on an other date. An entrance test could contain the topics from the actual lecture and from the base and instructions for the labo session.

Grading tests (including calculation) at least for 50% (in sum from tests).

Examination conditions: Student has to pass a written test comprising the topics discussed during the lectures and tutorials, including assigned individual study. The exam is graded according to the ECTS scale, to pass the exam, the test must be evaluated at least at 50 %.

Syllabus of lectures:

1. Objectives of the subject. Basic principles of physical chemistry. Physical and chemical properties of compounds. Basic calculations.

2. Mixtures of compounds-gases.

3. Mixtures of compounds-solid and liquid compounds.

4. Evaporation, saturated vapour. Humidifiers and vaporizers of anaesthetic compounds.

5. Electrochemical potential, electrodes. Nernst equation. Electrodes of the first type. Electrochemical cell and half-cell. Application in biomedical engineering.

6. Electrodes of the second type. Solubility product. Reference electrodes. ECG, EEG and EMG electrodes.

7. Redox potential. Inert electrodes. Calculation of redox potential. Application in BME.

8. Membranes-types, properties and application. Osmotic pressure. Ion-sensitive electrodes. Acidity of solutions, pH. Measurement of pH.

9. Stability of materials and corrosion. Anodic reactions. Corrosive speed.

10. Electrolysis, conductivity of solutions and its measurement. Other methods for analysis of solutions and gases. Applications in BME.

11. Optical absorption. Spectrophotometry, etc. Application in BME.

12. Fluorescence a phosphorescence. Sensors for pH, pO2, pCO2 and SO2 measurement based on optical principles.

13. Advanced analytical methods and equipment. Mass spectroscopy, nuclear magnetic resonance, atomic absorption spectrophotometry, etc.

14. Thermodynamics-basic principles and calculations.

Syllabus of tutorials:

1. Chemical laboratory-equipment and usage. Safety in the laboratory, safety procedures.

2. Basic calculations in physical chemistry. Calculations with gases. Calculations from chemical equations.

3. Experiments confirming calculations from chemical equations-solid compounds.

4. Experiments confirming calculations from chemical equations-liquids.

5. Experiments confirming calculations from chemical equations-gaseous compounds.

6. Electrolysis of solutions.

7. Well-defined potentials. Measurement of electrodes of the first type.

8. Measurement of pH. Laboratory preparation of pH standards. Calibration of pH-measuring system.

9. Measurement of redox potentials.

10. Experiments with fluorescence and phosphorescence.

11. Optical analytical methods, spectrophotometric measurements.

12. Measuremnt of conductivity.

13. Titration based on conductivity.

14. Analysis using AAS.

Study Objective:

The aim of the subject is to give students the basic principles of the physical chemistry that are essential for design and work of the medical equipment, in clinical trials and in clinical practice. Application of these principles in the practice is explained.

Study materials:

[1] Atkins, P., Paula, J.: Atkins' Physical Chemistry. (Eighth Edition). Oxford University Press, Oxford, 2006.

[2] Raff, M. L.: Principles of Physical Chemistry. (Paarts 1 and 2). Prentice Hall, Upper Saddle River, 2001.

The course is a part of the following study plans: